Studies on Chloramphenicol. XVII

Free Radical Cyclizations, Xvii. Mechanistic Studies

Free radical cyclizations of the 4-phenylbutyl radical and analogues carrying naphthyl and vinyl groups instead of phenyl have been studied. A typical reaction scheme is given below involving closures to fiveand six-membered rings. Competition rate studies for the various types of ring closure were performed with deuterated analogues. The results can be used as an efficient mechanistic tool for...

X-ray studies on phospholipid bilayers. XI. Interactions with chloramphenicol.

Chloramphenicol is a widely used antibiotic with low levels of toxicity. However, scanning electron microscopy revealed morphological changes in human erythrocytes when they interacted in vitro with therapeutical concentrations of chloramphenicol. To explain this shape change, a study concerned with the possible interactions of this antibiotic with bilayers built-up of phospholipids located in ...

Studies on Amphibian Metamorphosis Xvii. Influence of Non-living Annular Tympanic Cartilage on Tympanic Membrane Formation

INTRODUCTION THE tympanic membrane of the adult frog is divisible into three histologically distinct parts, viz. an inner epithelial layer, continuous with the mucous membrane of the tympanic cavity, the former being closely applied to a thin lamina propria conforming in shape and area to that of the annular tympanic cartilage to which it is attached at its peripheral borders. The third and out...

Xvii. Neurology

Accommodation is most often seen in association with convergence, and it is well known that a variety of clues, particularly binocular fusion, drives convergence. Is there a monocular accommodation reflex, and if so, what is its stimulus? It is important to try to understand such a physiological error mechanism a widely distributed, unlearned, involuntary mechanism present in restricted monocul...

Chloramphenicol.